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Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Research has shown increased phosphorylation of extracellular signal-regulated kinases (ERK) 1 and 2, along with their downstream targets, including c-Fos, c-Jun, and Egr-1, which are molecules involved in cell growth, migration, and angiogenesis

Five mechanistic axes are documented: 1

Large hiatal hernias can induce electrocardiographic changes, and atrial tachycardia, atrial fibrillation, supraventricular tachycardia, atrial flutter, and T wave changes have all been previously reported, but the exact mechanism of such arrhythmias is not well understood

This aligns with the biological reality of metabolic adaptation
