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Moreover, IGF-1R activation downregulates cell cycle suppressors p27 kip1 , p57 kip2 , and PTEN [25, 26], indicating multiple pathways are involved

Cigarette smoke can exacerbate the pro-inflammatory function of macrophages by inducing metabolic reprogramming (enhanced glycolysis)forming a cascade of metabolic remodelingmacrophage activationinflammation enhancement (116)

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Berries have antioxidants that promote healing and protect against further cell damage
