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Description
As a result, activation of ER during a HFD and genetic leptin resistance improves insulin resistance induced by ectopic lipid accumulation in skeletal muscle (148150, 193)
Biochemistry 51 , 68046815 (2012)

doi: 10.3945/ajcn.2008.27300

The primary mechanism of ferroptosis involves the catalytic oxidation of polyunsaturated fatty acids on cell membranes, mediated by divalent iron or lipoxygenases, leading to lipid peroxidation and subsequent cell death

7 NRF2-driven SLC7A11 expression increases xCT activity, which is sufficient and required for increased production of glucose-derived cysteine conjugates
