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doi: 10.1016/j.peptides.2006.10.005

Whereas proper internal duct development is dependent on testosterone as the intracellular mediator, development of the urogenital sinus and tubercle into the external genitalia, urethra and prostate requires conversion of testosterone to dihydrotestosterone (DHT) by the isoenzyme 5-reductase-2

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VPS35 in dopamine neurons is required for endosome-to-golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for alpha-synuclein degradation and prevention of pathogenesis of Parkinson's disease

Tan, Q., Zhang, J