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and it has been widely used in treating HT in TCM

2021 Jul 26;95(16):e0018721

Alanine and pyroglutamic acid were significantly reduced in the BPD group when compared to preterm controls

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Decreased concentrations of folate in the CSF also may be seen in several other neurologic disorders, including with Rett syndrome, Aicardi-Goutires syndrome, 3-phosphoglcerate dehydrogenase deficiency, dihydropteridine reductase deficiency, aromatic amino acid decarboxylase deficiency, Kearns-Sayre syndrome, and mitochondrial complex I encephalomyopathy, as well as with chronic exposure to antifolate drugs or anticonvulsant medications (38