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However, when production becomes irregular or excessive, it leads to uneven skin tone and dark patches, commonly known as hyperpigmentation

doi: 10.1016/j.ab.2011.03.026
Analysis of protein-coding genetic variation in 60,706 humans

Heart Conditions: Caution is needed with congestive heart failure or severe heart issues

doi: 10.3389/fbioe.2020.00339 Received 29 December 2019 Accepted 27 March 2020 Published 23 April 2020 Volume 8 - 2020 Edited by Wen-Yong Lou, South China University of Technology, China Reviewed by Ping Lan, Jinan University, China