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3 Zebrafish models for uncovering therapeutic mechanisms of phytochemicals in alcohol-related liver disease Alcohol-related liver disease (ALD), a major healthcare burden stemming from chronic excessive alcohol consumption, progresses through a complex pathogenesis involving metabolic disruption, oxidative stress, and inflammation

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M., Akerlund, J., Mittge, E

A similar result was obtained in a murine model of HHcy (i.e., CBS +/ mice), where CBS deficiency led to an up-regulation of CSE in the mouse heart, thus confirming the imbalance in the transsulfuration pathway under HHcy conditions