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Normally, cells produce small amounts of pro-oxidative agents, which serve important defensive roles, but antioxidant enzyme systems like glutathione and others inactivate them due to their ability to neutralize free radicals

Clinical studies have also found a 200-fold increased risk of HCC in people with iron overload, such as HH patients

Liu Y., Yang Z., Du Y., Shi S., and Cheng Y., Antioxidant Interventions in Autism Spectrum Disorders: A MetaAnalysis, Progress in NeuroPsychopharmacology & Biological Psychiatry 113 (2022): 110476

The elevated production of OPT is typically observed in APAP-overdosed mice [144], in patients with hepatic injury [142], and in fasted mice [145]

doi: 10.1038/s41467-020-14676-4 46 LiuZ.WangR