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Currently children with high heteroplasmy levels of severely deleterious mtDNA mutations experience the progressive loss of mental and physical capabilities, often experiencing unremitting discomfort and pain and many will ultimately progress to premature death

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doi: 10.2147/dmso.S182406 53 RuegseggerGNBoothFW

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Both FCCP treatment and glutamine deprivation under cystine-deprived conditions induced expression of mitophagy markers, including PINK1, and were associated with a reduction in mitochondrial marker TOMM20 (Fig

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This decline in mitochondrial membrane potential shows a strong correlation with neurodegenerative disorders

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Washington, DC: ASM Press (2006)

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