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It is also a potent antioxidant

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Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis

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Semi-saturation mutagenesis on the conformationally flexible H241 residue shows that only H241N and H241Q retained low activity, indicating that H241 is vital for the conformation required to bind PLP and tyrosine

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Theoretical concerns include excessive NAD+ elevation in individuals with preexisting metabolic disorders or mitochondrial dysfunction

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