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Figure 6 schematizes the pathways that lead to symptoms of Huntingtons disease as a consequence of misfolded mutant Htt

These findings suggest that kyphotic deformity alters spinal biomechanics, leading to increased stress on the anterior column and accelerating disc degeneration

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However, in a world of plenty, this advantage would turn into a disadvantage and give fast increases in body weight, hyperinsulinemia, and the development of metabolic syndrome problems early on (reviewed by Dunger et al (48)