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Classification of AC Separations AC separations are classified into six types (Type I to Type VI) based on the severity of ligament damage and degree of separation: Type I: Minor sprain with no displacement Type II: Partial dislocation with rupture of the AC ligament Type III: Complete dislocation with tearing of both AC and coracoclavicular (CC) ligaments Types IV-VI: Severe dislocations involving displacement of the clavicle in various directions, typically requiring surgery Types I to III are typically managed conservatively, whereas Types IV to VI may require surgical intervention

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EJ Antibiot (Tokyo),1981 16

Any important protocol modification such as changes to eligibility criteria, outcome analyses will be thoroughly communicated with DSMB members and will obtain amendment clearance from the institutional review board (IRB)