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Most of these methods are based on the same principle: a synthetic colored radical or redox-active compound is generated, and the ability of a biological sample to scavenge the radical or reduce the redox-active compound is measured using a spectrophotometer

However, recent liver-specific GCK activators have challenged this hypothesis, as they are capable of decreasing blood glucose without such an effect on hepatic lipid metabolism (335)

This allows it to pass through the blood-brain barrier making it the most bio-available, and thus most easily absorbed, form