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A growing body of evidence supports a consideration that tetratricopeptide repeat proteins with carboxylate clamps are also required for a normal HSP70HSP90 interaction, bringing both of them geometrically closer to client proteins ( HSP110 Among the four members of HSP110 family, HSP105 (HSP110) shows the strongest interaction with HSP70s (Teshima et al., 2021)

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