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For example, sulforaphane reduced contrast agent-induced kidney damage in rats by increasing Nrf2 nuclear translocation and upregulating the expression of HO-1 and NQO-1 (13)

Nat Immunol 23:13091316 Gurtner A, Borrelli C, Gonzalez-Perez I, Bach K, Acar IE, Nunez NG, Crepaz D, Handler K, Vu VP, Lafzi A et al (2023) Active eosinophils regulate host defence and immune responses in colitis

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Continuous ROS production results in oncogene and tumor suppressor gene changes, as well as chromosomal abnormalities by oxidative genome damage, which includes the oxidation of guanine to form 8-OhdG and 8-oxo,7,8-dihydroguanosine (8-OHG) in RNA and DNA (100)