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Hormetic Response Mechanisms Hormesis describes the biological phenomenon where low doses of a stressor produce beneficial adaptive responses while higher doses become harmful

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Lactate accumulation is commonly accepted as a sign of mitochondrial ill-health, indicating that mitochondria are not able to utilize either glucose or lactate as the source of energy [24]

Mechanistically, their anti-inflammation and anti-oxidation properties and metabolic modulations underlie these pharmacological activities for protection against cell injuries, restoration of cellular function, and maintenance of physiological and metabolic homeostasis (Figure 2), which is discussed across various tissues and disorders in this review