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doi: 10.1038/s41598-017-01576-9 243 SinhaTVich VilaAGarmaevaSJankipersadsingSAImhannFCollijVet al

CD4 + T lymphocytes can secrete cytokines such as interferon, IL-6, IL-17 and TNF-, which further induce the production and release of MMP and the activation and aggregation of neutrophils in the body, thereby destroying lung tissue and activating elastase, ultimately leading to elastin hydrolysis and emphysema formation

Variants in GSS cause GSS protein deficiency or reduced GSS activity, resulting in lower GSH levels

The ATD domains in both GluK3-SYM and GluK3-UBP310 complex have a N-shaped arrangement with an apparent 2-fold symmetry at dimer and dimer of dimers interface, while the TM domains exhibit 4-fold symmetry (Figs 2 and 3ad

Based on these results, intervals for stage II including elephants B and C were extended to 4 weeks between prime-boost vaccinations and 6 weeks between first and second vaccination cycles (Fig