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Mechanistically, these factors lead to (or are accompanied by) phenotypic conversion of various cell types into osteoprogenitor cells via de novo or increased expression, respectively, of the potent transcription activator RUNX2, which triggers the expression of downstream calcification-promoting proteins such as alkaline phosphatase (186188)

Expanded HHVBP Model In the CY 2022 HH PPS final rule (86 FR 62292 through 62336) and codified at 42 CFR part 484 subpart F, we finalized our policy to expand the HHVBP Model to all Medicare certified HHAs in the 50 States, territories, and District of Columbia beginning January 1, 2022

Kell, A., Ventura, N., Kahn, N

Insert needle, inject air into vial (equalizes pressure) 4

doi: 10.1038/ncb2021