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[7] High-dose methionine may antagonize the therapeutic effect of L-dopa-carbidopa regimens by increasing peripheral methylation of the drug complex, potentially reducing central bioavailability

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However, when the assay was repeated with 5-amino-6-fluoro-1MQ, an analogue of 5-amino-1MQ that did not interfere with the NAMPT assay, no inhibition of NAMPT was observed with analogue concentrations between 30 and 600 M (data not shown)