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In the study by Corral-Jara et al., the researchers employed a multi-omics approach and discovered that EC metabolites derived from the gut microbiota, particularly -pentalactone-bound metabolites, exert significant anti-inflammatory effects by synergistically regulating mRNA, miRNA, lncRNA, and protein expression

[DOI] [PubMed] [Google Scholar] Huang Y

Serotonergic dysregulation is linked to sleep problems in Parkinsons disease

The latter is a competitor of 2-Oxoglutarate-dependent dioxygenases such as Ten-eleven translocation methylcytosine dioxygenase and therefore induces DNA hydroxymethylation and gene upregulation 52

These changes resulted in elevated intracellular Fe 2+ levels and the downregulation of p-STAT3, SLC7A11, and GPX4 levels (57)