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5.1.7 Anticancer drugs 5.1.7.1 Cisplatin Cisplatin ( cis- diamminedichloroplatinum II) has become the chemotherapeutic agent of choice in the treatment of several solid tumours, particularly testicular and ovarian cancers (Einhorn & Donohue, 1977)

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Prostate cancer cells co-cultured with adipocytes increase expression of IL1- to stimulate adipocyte lipolysis in a vicious positive feedback loop that decreases prostate cancer cell sensitivity to docetaxel and upregulates prostaglandin E2 (PGE2) synthesis in adipocytes, a prostate cancer pro-survival signal (212)