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The absence of mucin, a highly glycosylated polymeric protein in the mucous layer, makes an animal vulnerable to intestinal inflammation, which leads to the development of spontaneous colitis and confers a predisposition to the development of colorectal cancers (Fig
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In addition, the patients who were newly sensitized after LVAD implant and did not reach transplantation had a higher level of allosensitization (27.9% vs

Peer review Peer review information Nature thanks Ignas Snellen and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
Accordingly, we could not address the issue of having different numbers of annual assessments