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Mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insulin sensitivity and metabolic homeostasis

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The results showed that 85% of the patients using guselkumab achieved an IGA score of 0 or 1 at week 16, and 73% achieved PASI 90 response, which was significantly superior to placebo and adalimumab

Lancet Oncol 23:6576 Mikhael J, Belhadj-Merzoug K, Hulin C (2021) A phase 2 study of isatuximab monotherapy in patients with multiple myeloma who are refractory to daratumumab