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Certain painkillers (NSAIDs), antibiotics like tetracyclines, antimalarial drugs, some chemotherapy drugs, and even some heavy metals are common causes of dark lips induced by medications 2

doi: 10.1186/1423-0127-19-32 55 StasiMAScioliMGArcuriGMatteraGGLombardoKMarcelliniMet al
For this reason, dosing timing relative to meals and exercise can influence metabolic outcomes

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doi: 10.1309/M7D5KTVYYE51XYQA
