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The evidence points to the involvement of NO in several features of the disease, such as bloodbrain barrier disruption, oligodendrocyte damage and demyelination, axonal degeneration, and loss of function as a result of reduced axonal conduction

Thiamine is necessary for maintaining intestinal epithelial cell bioenergetics, and reduced activity of thiamine-dependent enzymes may lead to a defective gut barrier

This single step dramatically improves shelf life and safety

B12 overdose symptoms include skin rashes, itching, upset stomach (nausea, vomiting, diarrhea), b12 overdose headache, and feeling anxious or nervous

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