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When MSTN bind its receptors ALK5 and ActRIIB, Smad 2/3 gets involved in promoting the proliferation of fibroblasts, their differentiation into myofibroblasts, and expression of ECM proteins, thus contributing to fibrogenesis [59]
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Melanocytes are located in the deepest part of the surface layer of the skin, the epidermis, so pigmentation issues can arise rather easily

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