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In the 1970s, NAC was used to treat acetaminophen (paracetamol) overdose [14, 15]

All pretreatments increased binding of autologous IgG as well as of purified anti-band 3 NAbs and binding was inhibited by purified band 3 protein or by restoration of the protein SH groups (Beppu et al., Oxidation or a treatment with a clustering agent and cross-linking of the generated clusters evidently simulates the prerequisites for clearance of RBC, but does not explain how band 3 clusters are formed during in vivo aging

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In addition, R169 and its adjacent amino acids have significant conservation across various species (Fig

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