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Arterioscler Thromb Vasc Biol 2008;28:1857-65

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TYR from Juglans regia (walnut, jr PPO1) is expressed in vivo as a latent 66.8 kDa pro-enzyme consisting of three domains 15 : an N-terminal chloroplast transit peptide (~12 kDa) 15 , the catalytically active domain (~39 kDa) and the C-terminal domain (~16 kDa) that shields the entrance to the catalytic pocket and keeps the enzyme in a latent state

Gene editing in a Myo6 semi-dominant mouse model rescues auditory function

doi: 10.1006/taap.1993.1085