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Mater Chem Phys 199:609615

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726 In addition, nicotinamide adenine dinucleotide (NAD) augmentation by, e.g., oral nicotinamide riboside (NR) intake, has been shown to increase the transcription of both proteasomal and lysosomal components and decrease serum and CSF inflammatory cytokine levels in PD patients, 736 suggesting that it may be explored whether the targeting of age-associated declines in NAD synthesis could ameliorate age-related decreases in protein degradation pathways as well as inflammaging