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Chronic administration of high doses of oral levocarnitine in patients with severely compromised renal function or in ESRD patients on dialysis may result in accumulation of the potentially toxic metabolites, trimethylamine (TMA) and trimethylamine-N-oxide (TMAO), since these metabolites are normally excreted in the urine

Additionally, metabolic changes in the serum of MA abusers showed decreased levels of threonine, proline, methionine, and TCA intermediates, such as lactic acid, citric acid, pyruvic acid, and succinic acid 66

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[DOI] [PubMed] [Google Scholar] Ramsden C

A study has shown that bezlotoxumab binds to two homologous but distinct epitopes on the CROP domain, thereby preventing TcdB from binding to the surface of host cells (Orth et al., 2014)