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Safety and effectiveness in pediatric patients have not been established

7425 - 7434, Journal articles | 2020 Zhang L

M.ShenD

These modifications illustrate a broader trend of tailoring drug scaffolds to improve safety profiles, potentially reshaping asthma therapy and setting new standards for heterocyclic design

The text also covers representative drugs of the major biologics currently used in the treatment of HS and describes the IRAK4 inhibitor Zimlovisertib and the IRAK4 degrader KT-474, along with a discussion of the current status of drugs that inhibit IRAK4 in the treatment of HS and the challenges they face