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Bristow MR, Thompson PD, Martin RP, Mason JW, Billingham ME, Harrison DC

Fusion arrest by polyubiquitination and proteasomal degradation of mitofusins (Mfn1 and Mfn2) by Parkin is required for mitophagy (Figure 4.4)

According to Cant et al., Cell Metabolism , increased NAD stimulates PGC-1 activity, driving mitochondrial biogenesis and substrate flexibility

doi: 10.3389/fphys.2018.00477 13

Pro-inflammatory cytokine levels : We compared the circulating levels of cytokines IL-1 , IL-1 , IL-2, IL-6, IFN- and TNF- in the sera obtained from sham-operated and MI rats with and without chronic exposure to tobacco (Figure 7)