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For example, accumulation of advanced glycation end-products via nonenzymatic alterations on long-lived proteins upon aging disturbs the normal chaperone activity (Table 2)

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Alongside this, single-cell epigenomics offers a powerful tool for dissecting the heterogeneity and uncovering resistance vulnerabilities at the individual-cell levelpotentially illuminating new biomarkers and therapeutic entry points (Liu et al., 2024)

Delayed onset of persistent discogenic axial and radiating pain after a single-level lumbar intervertebral disc injury in mice