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Despite prior concerns regarding potential adverse effects, a 23-h fasting regimen mitigates metabolic abnormalities observed in Pcca-mutated mice by reducing propionate production from the microbiome and enhancing propionyl-CoA disposal for gluconeogenesis and fatty acid oxidation to acetyl-CoA.
In addition, in a host-cell reactivation assay using cisplatin-treated plasmid, we did not detect any difference in DNA repair capacity