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Unlike MSCs, which undergo senescence after a limited number of passages or with aging [59, 62], MSC-Exos do not exhibit signs of senescence and are more cost-effective and easier to produce at scale for clinical applications [63, 64]

They are not FDA-approved to diagnose, treat, cure, or prevent any disease

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Diabetic toxicity, including hyperglycemia, hyperlipidemia, and cancer, has been linked to mutations in the FOXO genes

First generation deficient animals are more sensitive to stresses, especially when also deficient in vitamin E, and more sensitive to toxicity of certain chemicals and heavy metals such as mercury