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Beyond IDH-mutant disease, plasma profiling of arginine and kynurenine may provide complementary insight into residual immunosuppressive disease burden, as supported by metabolomics profiling studies identifying systemic metabolic differences associated with drug sensitivity in primary AML [13,61]

S2CID 40296724

& Maness, L

108,109 These findings provide a prime collateral lethality therapeutic strategy for the treatment of a substantial fraction of GC or PDAC patients
