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Imagine you are throwing a coin

So far, there has been only one potential drug candidate for preventing the development of oxaliplatin-induced acute and delayed CIPN, namely, calmangafodipir, a mitochondrial manganese superoxide dismutase mimetic, which is currently being studied in a placebo-controlled, double-blinded randomized phase III study [24]

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Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection

Overall, melatonin's ability to affect multiple pathways involved in the pathophysiology of FM makes it a promising adjunctive treatment for this chronic pain syndrome [66, 67]