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Phagocytosis and removal of damaged myelin seems to be one of the major roles of microglia in this model and it is well known that removal of myelin debris is a prerequisite of successful remyelination
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Pollak MN, 2012, 'A phase II trial of neoadjuvant metformin in prostatic adenocarcinoma with serum and tissue biomarker evaluation.', Journal of Clinical Oncology , 30, pp
The trial also showed that the combination produced dose-dependent, sustained weight loss without concerning additional adverse effects the side effect profile was broadly consistent with what would be expected from each individual agent
