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Therefore, Nrf2 could serve as a potential target for the treatment of advanced kidney cancer in the future

This stabilization of NRF2, through reduced ubiquitination, ultimately inhibits ferroptosis 46

Endogenous nonprotein antioxidants Four well-known main antioxidant mechanisms against oxidative damage have been largely studied (1) sequestration of transition metal ions, (2) scavenging and quenching of ROS and RNS, (3) ending of chain reactions by free radicals, and (4) molecular repairing of radicals damages

From the CSF, FR-containing vesicles/exosomes are taken up by ependymal cells by a putative FR binding protein (i.e