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In the second group of 8 patients after 24 y

Salvia constituents can influence multiple biological mechanisms related to cognition, such as effects on amyloid-, neurotrophins, inflammation, cholinergic activity, oxidative stress, and behaviors associated with anxiety and depression (Lopresti, 2017)

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10.1038/s41422-021-00468-y 142 PanJ.LiH.MaJ.TanY

Similarly, it was also shown that in primary mesencephalic cultures, TPNA10168 upregulated HO-1 in astrocytes, thereby protecting dopaminergic neurons from neurodegeneration