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We have previously demonstrated that these fluxes of cytosolic glutamate can occur without significant increases in oxidative stress or altered cell viability (16)

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Meanwhile, while the protein levels of SLC7A11 remained unchanged, the expression of SLC3A2 and GPX4 was inhibited by iron overload, with theaflavins showing therapeutic potential (Fig

Miyazawa T, Burdeos GC, Itaya M et al (2019) Vitamin E: regulatory redox interactions

(2018) Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death, Biomed