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These findings were further corroborated by Western blot analysis, in which we observed increased -H2AX expression, decreased pNPM1 (T199) protein levels and increased expression of autophagosome LC3A/B proteins (Fig

This is consistent with published reports that ROS induced GSDMD cleavage and pyroptosis in cancer cells [42]

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Research-use disclaimer: This article is provided for educational and informational purposes only and describes findings from laboratory, cell-culture, and animal research