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Work with pesticides and organophosphate sheep dips

They can be targeted, sophisticated, and surprisingly convincing

The ability to precisely regulate the durability and reversibility of the therapeutic effects is a key consideration for the clinical translation of next-generation technologies

Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction

Not in a phase 1 safety trial