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The carbonic anhydrase inhibitor methazolamide is metabolized to glutathione S -conjugate and a cysteine S -conjugate
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Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
In addition to the examples listed in the last section, embryonic deletion of Dnmt3a results in neuronal dysfunction, such as hypoactivity, motor abnormalities, decreased neuromuscular function, fewer motor neurons, and a shortened lifespan [73]
