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The deletion of ATF4, an upstream factor of ChaC1, in embryonic fibroblasts, results in a ferric oxide-dependent death phenotype, emphasizing the role of ATF4 as a downstream molecule of the eIF2/ATF4 pathway (117)

In contrast to what observed in treatment-nave IPF patients, serum from IPF patients treated with pirfenidone failed to induce the generation of ROS and collagen synthesis in HPASMC (Fig

Additionally, recent findings indicate that taurine produced by Lactobacillus rhamnosus markedly decreases endometrial cancer cell viability, highlighting its targeted anticancer effects (Lawore et al., 2024)