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Inflammation within the TME is widely recognized to promote tumorigenesis by interfering with anti-tumor immunity, reshaping the TME towards a tumor-supportive niche, and acting as tumor-promoting signals for epithelial and cancer cells 10

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Exp Hematol Oncol 5(1):27 Dinkova-Kostova AT, Fahey JW, Wade KL, Jenkins SN, Shapiro TA, Fuchs EJ et al (2007) Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts

Chemotherapy-induced mucosal injury is also influenced by pro-inflammatory cytokines such as TNF, interferon- (IFN ), interleukin 1 (IL-1), and IL-6 [76, 77]