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Full therapeutic doses are a separate and more promising story, now in trials for depression and, as covered above, in an early test in Parkinsons

The Science

Presumably, selenium decreases disease severity, in part, via augmenting the expression and activity of selenoproteins, such as GPx1

Despite their reduction through macrophage phagocytosis, the inflammatory response persists due to the continued macrophage engagement with MSU crystals (52), contributing to the chronic inflammation characteristic of HUA

Turning now to the second level of severity, moderate, it is typical to see affected patients experience experience the two symptoms described above, in addition to metabolic acidosis