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doi: 10.1097/MD.0000000000006615 68 LiuG.SunW.WangF.JiaG.ZhaoH.ChenX.et al

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7 Smoking and tobacco use also increase oxidative stress while reducing antioxidant defenses

NLRP3 inflammasome in neuroinflammation and central nervous system diseases

Brain imaging studies show that changes are going on with multiple neurotransmitters, including the cholinergic, noradrenergic, and dopaminergic circuits.[ref] REM sleep behavior disorder is strongly linked to eventually developing Parkinsons disease