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Historically, mean weight loss has been modest with AOMs although with newer agents and combination therapy, higher degrees of weight loss can be achieved

For instance, the induction of ferroptosis disrupts tumor cell redox homeostasis and promotes immunogenic cell death, thereby enhancing T cell infiltration and activation within the tumor microenvironment (127)

Cannabinoid receptor 2 is necessary to induce toll-like receptor-mediated microglial activation

Biochem Biophys Res Commun 482:980986 Shao S, Wang GL, Raymond C et al (2017) Activation of sonic hedgehog signal by purmorphamine, in a mouse model of Parkinsons disease, protects dopaminergic neurons and attenuates inflammatory response by mediating PI3K/AKt signaling pathway