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Moreover, ionizing radiation can induce pyroptosis in cancer cells expressing the GSDME protein, such as those found in lung, liver, breast, and glioma cancers [189]
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Cell Reports , 44 (9), 116139 Meza-Perez S., Liu M., Silva-Sanchez A., Morrow C

Shaking creates a shearing force that can physically break the delicate amino acid bonds that form the peptide